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Article

Proxy gene-by-environment Mendelian randomization study of the association between cigarette smoking during pregnancy and offspring mental health.

International journal of epidemiology - 5 Oct 2023

Sallis Hannah M, Wootton Robyn E, Davey Smith George, Munafò Marcus R

Abstract excerpt

BACKGROUND: Smoking prevalence is higher among individuals with schizophrenia or depression, and previous work has suggested this relationship is causal. However, this may be due to dynastic effects, for example reflecting maternal smoking during pregnancy rather than a direct effect of smoking. We used a proxy gene-by-environment Mendelian randomization approach to investigate whether there is a causal effect of...

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Identifiers

PMID: 36860174
DOI: 10.1093/ije/dyad022
PMCID: PMC10555861

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