Article
Protocol for comparing gene-level selection on coding mutations between two groups of samples with Coselens.
STAR protocols - 17 Mar 2023
Iranzo Jaime, Gruenhagen George, Calle-Espinosa Jorge, Koonin Eugene V
Abstract excerpt
The study of genes that evolve under conditional selection can shed light on the genomic underpinnings of adaptation, revealing epistasis and phenotypic plasticity. This protocol describes how to use the Coselens package to compare gene-level selection between two groups of samples. After installing Coselens and preparing the datasets, a typical run on a laptop takes less than 10 min. Coselens is best suited to...
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