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Hypermethylation of Smad7 in CD4+ T cells is associated with the disease activity of rheumatoid arthritis

9 Feb 2023

Abstract excerpt

Background Smad7 is protective in a mouse model of rheumatoid arthritis. Here we investigated whether Smad7-expressing CD4+ T cells and the methylation of Smad7 gene in CD4+ T cells contribute to the disease activity of RA in patients. Methods Peripheral CD4+ T cells were collected from 35 healthy controls and 57 RA patients. Smad7 expression by CD4+ T cells were determined and correlated with the clinical...

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PMID: 36845150
DOI: 10.3389/fimmu.2023.1104881

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