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Article

Are SMAD2/4/7 genetic variants associated with rheumatoid arthritis susceptibility and severity?

Clinical and experimental rheumatology - 1 Jul 2023

Wajda Anna, Stypińska Barbara, Czarnecka Magdalena, Hasan Diana, Jarończyk Małgorzata, Haładyj Ewa, Romanowska-Próchnicka Katarzyna, Olesińska Marzena, Pawlik Andrzej, Paradowska-Gorycka Agnieszka

Abstract excerpt

OBJECTIVES: SMADs play one of the key roles in the TGFβ signalling pathway. Therefore, through their involvement in the immune response as well as in the fibrosis process, these proteins appear to take on one of the essential functions in the pathogenesis of autoimmune connective tissue diseases such as RA. This study aimed to investigate the association of selected SNPs in SMAD2/4/7 with RA risk in the Caucasian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36377587
DOI: 10.55563/clinexprheumatol/oqu492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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