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Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes.

Signal transduction and targeted therapy - 27 Feb 2023

Casado Pedro, Rio-Machin Ana, Miettinen Juho J, Bewicke-Copley Findlay, Rouault-Pierre Kevin, Krizsan Szilvia, Parsons Alun, Rajeeve Vinothini, Miraki-Moud Farideh, Taussig David C, Bödör Csaba, Gribben John, Heckman Caroline, Fitzgibbon Jude, Cutillas Pedro R

Abstract excerpt

Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landscape of poor prognosis AML we profiled 74 patients from two different centres (in UK and Finland) at the proteomic, phosphoproteomic and drug response phenotypic levels. These...

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Share to Acute Myeloid Leukemia Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Identifiers

PMID: 36843114
DOI: 10.1038/s41392-022-01288-1
PMCID: PMC9968719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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