Article
Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes.
Retrovirology - 25 Jul 2014
Young George R, Mavrommatis Bettina, Kassiotis George
Abstract excerpt
BACKGROUND: A substantial proportion of both the mouse and human genomes comprise of endogenous retroelements (REs), which include endogenous retroviruses. Over evolutionary time, REs accumulate inactivating mutations or deletions and thus lose the ability to replicate. Additionally, REs can be transcriptionally repressed by dedicated mechanisms of the host. Nevertheless, many of them still possess and express...
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