Article
EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation.
Neuron - 3 May 2023
Bademosi Adekunle T, Decet Marianna, Kuenen Sabine, Calatayud Carles, Swerts Jef, Gallego Sandra F, Schoovaerts Nils, Karamanou Spyridoula, Louros Nikolaos, Martin Ella, Sibarita Jean-Baptiste, Vints Katlijn, Gounko Natalia V, Meunier Frédéric A, Economou Anastassios, Versées Wim, Rousseau Frederic, Schymkowitz Joost, Soukup Sandra-F, Verstreken Patrik
Abstract excerpt
Neuronal activity causes use-dependent decline in protein function. However, it is unclear how this is coupled to local quality control mechanisms. We show in Drosophila that the endocytic protein Endophilin-A (EndoA) connects activity-induced calcium influx to synaptic autophagy and neuronal survival in a Parkinson disease-relevant fashion. Mutations in the disordered loop, including a Parkinson disease-risk...
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