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Article

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.

Cell reports - 18 Oct 2016

Murdoch John D, Rostosky Christine M, Gowrisankaran Sindhuja, Arora Amandeep S, Soukup Sandra-Fausia, Vidal Ramon, Capece Vincenzo, Freytag Siona, Fischer Andre, Verstreken Patrik, Bonn Stefan, Raimundo Nuno, Milosevic Ira

Abstract excerpt

Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodegeneration in mice. Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and...

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Identifiers

PMID: 27720640
DOI: 10.1016/j.celrep.2016.09.058
PMCID: PMC5080600

Genes

FBXO32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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