Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation.

PloS one - 1 Jan 2016

Wu Ying-Yu, Kumar Ramesh, Iida Ryuji, Bagavant Harini, Alarcón-Riquelme Marta E

Abstract excerpt

The purpose of our study was to investigate the effects of the adaptor Bank1 in TLR7 signaling using the B6.Sle1.yaa mouse, a lupus model that develops disease through exacerbated TLR7 expression. Crosses of B6.Sle1.yaa with Bank1-/- mice maintained several B and myeloid cell phenotypes close to normal wild-type levels. Most striking was the reduction in total serum IgG antibodies, but not of IgM, and reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to B-Lymphocytes
Share to Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

Share to Lupus Erythematosus, Systemic

Share to Membrane Glycoproteins

Share to STAT1 Transcription Factor

Share to Toll-Like Receptor 7

Source

Open in PubMed Open full text

Identifiers

PMID: 27228057
DOI: 10.1371/journal.pone.0156302
PMCID: PMC4882053

Genes

TLR7
STAT1
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation.PMID 27228057Read ↗

Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity DevelopmentSemantic proximity Read ↗

The Role of BANK1 in B Cell Signaling and Disease.Semantic proximity Read ↗

Sle1ab mediates the aberrant activation of STAT3 and Ras-ERK signaling pathways in B lymphocytes.Semantic proximity Read ↗

Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus.Semantic proximity Read ↗

Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human StudiesSemantic proximity Read ↗

Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupusSemantic proximity Read ↗

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.Semantic proximity Read ↗

B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.Semantic proximity Read ↗

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.Semantic proximity Read ↗

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung diseaseSemantic proximity Read ↗

Sustained NPSLE-like phenotype in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2 mice.Semantic proximity Read ↗

Monogenic autoimmunity caused by TLR7 gain-of-functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.