Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.

Frontiers in immunology - 1 Jan 2023

Cardinale Christopher J, Chang Xiao, Wei Zhi, Qu Hui-Qi, Bradfield Jonathan P, Polychronakos Constantin, Hakonarson Hakon

Abstract excerpt

Introduction: Type 1 diabetes, a disorder caused by autoimmune destruction of pancreatic insulin-producing cells, is more difficult to manage when it presents at a younger age. We sought to identify genetic correlates of the age of onset by conducting the first genome-wide association study (GWAS) treating the age of first diagnosis as a quantitative trait. Methods: We performed GWAS with a discovery cohort of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Age of Onset

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bayes Theorem

Share to Diabetes Mellitus, Type 1

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to T-Lymphocytes

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 36817429
DOI: 10.3389/fimmu.2023.1101488
PMCID: PMC9930890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.PMID 36817429Read ↗

Genome-wide search for genes affecting the age at diagnosis of type 1 diabetes.Semantic proximity Read ↗

Genomic variants associated with age at diagnosis of childhood-onset type 1 diabetes.Semantic proximity Read ↗

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.Semantic proximity Read ↗

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles.Semantic proximity Read ↗

Association of genetic variation with age at diagnosis in type 1 diabetes.Semantic proximity Read ↗

Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific EffectsSemantic proximity Read ↗

Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.Semantic proximity Read ↗

CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets.Semantic proximity Read ↗

Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.Semantic proximity Read ↗

EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.Semantic proximity Read ↗

TCF19 Impacts a Network of Inflammatory and DNA Damage Response Genes in the Pancreatic β-CellSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.