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Article

MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma

3 Feb 2023

Abstract excerpt

MUC16/CA125 is one of the few oldest cancer biomarkers still used in current clinical practice. As mesothelium is an abundant source of MUC16 and a major contributor to stromal heterogeneity in PDAC, we investigated the regulation of MUC16 in tumor and stromal compartments individually. The trajectories constructed using the single-cell transcriptomes of stromal cells from KPC tumors demonstrated continuity in...

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PMID: 36816942
DOI: 10.3389/fonc.2023.1073820

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