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High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility

10 Feb 2021

Abstract excerpt

Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced cancers. HPV is epitheliotropic and its replication is tightly associated with terminal keratinocyte differentiation making production and purification of high titer virus preparations for research problematic, therefore alternative HPV production methods have been developed for virological and structural studies. In this...

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PMID: 33568731
DOI: 10.1038/s41598-021-83076-5

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