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Article

Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes.

Ophthalmology - 1 Jul 2023

Aboobakar Inas F, Kinzy Tyler G, Zhao Yan, Fan Baojian, Pasquale Louis R, Qassim Ayub, Kolovos Antonia, Schmidt Joshua M, Craig Jamie E, Cooke Bailey Jessica N, Wiggs Janey L

Abstract excerpt

PURPOSE: Genetic variants in regions that include the mitochondrial genes thioredoxin reductase 2 (TXNRD2) and malic enzyme 3 (ME3) are associated with primary open-angle glaucoma (POAG) in genome-wide association studies (GWASs). To assess their clinical impact, we investigated whether TXNRD2 and ME3 genetic risk scores (GRSs) are associated with specific glaucoma phenotypes. DESIGN: Cross-sectional study....

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Source

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Identifiers

PMID: 36813040
DOI: 10.1016/j.ophtha.2023.02.018
PMCID: PMC10330404

Genes

ME3
TXNRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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