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Article

Molecular Dynamic Simulations Unravel the Underlying Impact of Missense Mutation in Autoimmunity Gene PTPN22 on Predisposition to Rheumatoid Arthritis.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 2023

Pasha Usman, Nisar Haseeb, Nisar Hajira, Abid Rizwan, Ashraf Naeem Mahmood, Sadaf Saima

Abstract excerpt

Genetic mutations in various proteins have been implicated with increased risk or severity of rheumatoid arthritis (RA) in different population groups. In the present case-control study, we have investigated the risk association of single nucleotide mutations present in some of the highly reported anti-inflammatory proteins and/or cytokines, with RA susceptibility in the Pakistani subjects. The study involves 310...

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PMID: 36811459
DOI: 10.1089/jir.2022.0216

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