Article
Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions.
CPT: pharmacometrics & systems pharmacology - 1 May 2023
Loer Helena Leonie Hanae, Feick Denise, Rüdesheim Simeon, Selzer Dominik, Schwab Matthias, Teutonico Donato, Frechen Sebastian, van der Lee Maaike, Moes Dirk Jan A R, Swen Jesse J, Lehr Thorsten
Abstract excerpt
The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter- and intra-individual variability can be observed. Underlying causes include the effect of food intake on tacrolimus absorption as well as genetic polymorphism in the CYP3A5 gene. Furthermore, tacrolimus is highly susceptible to drug-drug...
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