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Article

Computational analysis of the sequence-structure relation in SARS-CoV-2 spike protein using protein contact networks.

Scientific reports - 17 Feb 2023

Guzzi Pietro Hiram, di Paola Luisa, Puccio Barbara, Lomoio Ugo, Giuliani Alessandro, Veltri Pierangelo

Abstract excerpt

The structure of proteins impacts directly on the function they perform. Mutations in the primary sequence can provoke structural changes with consequent modification of functional properties. SARS-CoV-2 proteins have been extensively studied during the pandemic. This wide dataset, related to sequence and structure, has enabled joint sequence-structure analysis. In this work, we focus on the SARS-CoV-2 S (Spike)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 36808182
DOI: 10.1038/s41598-023-30052-w
PMCID: PMC9936485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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