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Article

HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation.

The Journal of clinical investigation - 2 May 2022

Fan Yanxin, Murgia Marta, Linder Monika I, Mizoguchi Yoko, Wang Cong, Łyszkiewicz Marcin, Ziȩtara Natalia, Liu Yanshan, Frenz Stephanie, Sciuccati Gabriela, Partida-Gaytan Armando, Alizadeh Zahra, Rezaei Nima, Rehling Peter, Dennerlein Sven, Mann Matthias, Klein Christoph

Abstract excerpt

The relevance of molecular mechanisms governing mitochondrial proteostasis to the differentiation and function of hematopoietic and immune cells is largely elusive. Through dissection of the network of proteins related to HCLS1-associated protein X-1, we defined a potentially novel functional CLPB/HAX1/(PRKD2)/HSP27 axis with critical importance for the differentiation of neutrophil granulocytes and, thus,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35499078
DOI: 10.1172/JCI153153
PMCID: PMC9057593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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