Article
Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 2023
Farrar Jason E, Smith Jenny L, Othus Megan, Huang Benjamin J, Wang Yi-Cheng, Ries Rhonda, Hylkema Tiffany, Pogosova-Agadjanyan Era L, Challa Sneha, Leonti Amanda, Shaw Timothy I, Triche Timothy J, Gamis Alan S, Aplenc Richard, Kolb E Anders, Ma Xiaotu, Stirewalt Derek L, Alonzo Todd A, Meshinchi Soheil
Abstract excerpt
PURPOSE: Optimized strategies for risk classification are essential to tailor therapy for patients with biologically distinctive disease. Risk classification in pediatric acute myeloid leukemia (pAML) relies on detection of translocations and gene mutations. Long noncoding RNA (lncRNA) transcripts have been shown to associate with and mediate malignant phenotypes in acute myeloid leukemia (AML) but have not been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.