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Article

Severe thrombophilia in a factor V-deficient patient homozygous for the Ala2086Asp mutation (FV Besançon).

Journal of thrombosis and haemostasis : JTH - 1 May 2021

Castoldi Elisabetta, Hézard Nathalie, Mourey Guillaume, Wichapong Kanin, Poggi Marjorie, Ibrahim-Kosta Manal, Thomassen M Christella L G D, Fournel Alexandra, Hayward Catherine P M, Alessi Marie-Christine, Hackeng Tilman M, Rosing Jan, Morange Pierre-Emmanuel

Abstract excerpt

BACKGROUND: Coagulation factor V (FV), present in plasma and platelets, has both pro- and anticoagulant functions. OBJECTIVE: We investigated an FV-deficient patient (FV:C 3%, FV:Ag 4%) paradoxically presenting with recurrent venous thrombosis (11 events) instead of bleeding. METHODS/RESULTS: Thrombophilia screening revealed only heterozygosity for the F2 20210G>A mutation. Although thrombin generation in the...

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Identifiers

PMID: 33605529
DOI: 10.1111/jth.15274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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