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Article

Process intensification strategies toward cell culture‐based high‐yield production of a fusogenic oncolytic virus

13 Feb 2023

Abstract excerpt

Abstract We present a proof‐of‐concept study for production of a recombinant vesicular stomatitis virus (rVSV)‐based fusogenic oncolytic virus (OV), rVSV‐Newcastle disease virus (NDV), at high cell densities (HCD). Based on comprehensive experiments in 1 L stirred tank reactors (STRs) in batch mode, first optimization studies at HCD were carried out in semi‐perfusion in small‐scale cultivations using shake...

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PMID: 36779302
DOI: 10.1002/bit.28353

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