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Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

1 Feb 2022

Abstract excerpt

Organoid evolution models complemented with integrated single-cell sequencing technology provide a powerful platform to characterize intra-tumor heterogeneity (ITH) and tumor evolution. Here, we conduct a parallel evolution experiment to mimic the tumor evolution process by evolving a colon cancer organoid model over 100 generations, spanning 6 months in time. We use single-cell whole-genome sequencing (WGS) in...

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PMID: 36778661
DOI: 10.1016/j.xgen.2022.100096

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