Article
Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach.
Scientific reports - 10 Feb 2023
Katagiri Ryoko, Goto Atsushi, Nakano Shiori, Nakatochi Masahiro, Koyanagi Yuriko N, Iwagami Masao, Hanyuda Akiko, Yamaji Taiki, Sawada Norie, Nakamura Yohko, Nakamura Sho, Kuriki Kiyonori, Suzuki Sadao, Imoto Issei, Momozawa Yukihide, Oze Isao, Ito Hidemi, Tsugane Shoichiro, Wakai Kenji, Matsuo Keitaro, Iwasaki Motoki
Abstract excerpt
The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentrations were systematically selected according to the "GWAS Catalog" from all ethnic populations. For the SNP-vitamin...
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