A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.

doi:10.1038/s41467-020-20368-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.

Nature communications - 11 Jan 2021

Ong Jue-Sheng, Dixon-Suen Suzanne C, Han Xikun, An Jiyuan, Liyanage Upekha, Dusingize Jean-Cluade, Schumacher Johannes, Gockel Ines, Böhmer Anne, Jankowski Janusz, Palles Claire, O'Mara Tracy, Spurdle Amanda, Law Matthew H, Iles Mark M, Pharoah Paul, Berchuck Andrew, Zheng Wei, Thrift Aaron P, Olsen Catherine, Neale Rachel E, Gharahkhani Puya, Webb Penelope M, MacGregor Stuart

Abstract excerpt

Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Multivariate Analysis

Share to Neoplasms

Share to Pigmentation

Share to Risk Factors

Share to Sunburn

Share to Vitamin D

Source

Open in PubMed Open full text

Identifiers

PMID: 33431812
DOI: 10.1038/s41467-020-20368-w
PMCID: PMC7801600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.PMID 33431812Read ↗

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.Semantic proximity Read ↗

Vitamin D and overall cancer risk and cancer mortality: a Mendelian randomization studySemantic proximity Read ↗

Evaluating the effect of body mass index and 25-hydroxy-vitamin D level on basal cell carcinoma using Mendelian randomization.Semantic proximity Read ↗

Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.Semantic proximity Read ↗

Assessing the causal association between 25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization.Semantic proximity Read ↗

Genetically predicted vitamin D levels and risk of head and neck cancer: a mendelian randomization study.Semantic proximity Read ↗

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study.Semantic proximity Read ↗

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.Semantic proximity Read ↗

Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.Semantic proximity Read ↗

Insights into risk factors for basal cell carcinoma: a Mendelian randomization study.Semantic proximity Read ↗

Genetic evidence supporting the causal role of 25-hydroxyvitamin D levels in the prognosis of ER- breast cancer: A Mendelian randomization study.Semantic proximity Read ↗

Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.