Article
Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells.
Nature communications - 10 Feb 2023
Ross Ewan A, Turner Lesley-Anne, Donnelly Hannah, Saeed Anwer, Tsimbouri Monica P, Burgess Karl V, Blackburn Gavin, Jayawarna Vineetha, Xiao Yinbo, Oliva Mariana A G, Willis Jennifer, Bansal Jaspreet, Reynolds Paul, Wells Julia A, Mountford Joanne, Vassalli Massimo, Gadegaard Nikolaj, Oreffo Richard O C, Salmeron-Sanchez Manuel, Dalby Matthew J
Abstract excerpt
Mesenchymal stromal cells (MSCs) are multipotent progenitor cells that are of considerable clinical potential in transplantation and anti-inflammatory therapies due to their capacity for tissue repair and immunomodulation. However, MSCs rapidly differentiate once in culture, making their large-scale expansion for use in immunomodulatory therapies challenging. Although the differentiation mechanisms of MSCs have...
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