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Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis

9 Feb 2023

Abstract excerpt

Genetic studies have identified ≥240 loci associated with the risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mechanisms. Recent studies investigating mRNA expression in human pancreatic islets have yielded important insights into the molecular drivers of normal islet function and T2D pathophysiology. However, similar studies investigating microRNA...

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PMID: 36757889
DOI: 10.1073/pnas.2206797120

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