Article
AD-Syn-Net: systematic identification of Alzheimer's disease-associated mutation and co-mutation vulnerabilities via deep learning.
Briefings in bioinformatics - 19 Mar 2023
Pan Xingxin, Coban Akdemir Zeynep H, Gao Ruixuan, Jiang Xiaoqian, Sheynkman Gloria M, Wu Erxi, Huang Jason H, Sahni Nidhi, Yi S Stephen
Abstract excerpt
Alzheimer's disease (AD) is one of the most challenging neurodegenerative diseases because of its complicated and progressive mechanisms, and multiple risk factors. Increasing research evidence demonstrates that genetics may be a key factor responsible for the occurrence of the disease. Although previous reports identified quite a few AD-associated genes, they were mostly limited owing to patient sample size and...
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