Article
Associations of the circulating levels of cytokines with risk of amyotrophic lateral sclerosis: a Mendelian randomization study.
BMC medicine - 3 Feb 2023
Liu Bin, Lyu Linshuoshuo, Zhou Wenkai, Song Jie, Ye Ding, Mao Yingying, Chen Guo-Bo, Sun Xiaohui
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is accompanied by muscle weakness and muscle atrophy, typically resulting in death within 3-5 years from the disease occurrence. Though the cause of ALS remains unclear, increasing evidence has suggested that inflammation is involved in the pathogenesis of ALS. Thus, we performed two-sample Mendelian randomization (MR) analyses...
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