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Article

Brain-derived neurotrophic factor (BDNF) variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults.

Journal of sleep research - 1 Aug 2023

Ancelin Marie-Laure, Jaussent Isabelle, Ritchie Karen, Besset Alain, Ryan Joanne, Dauvilliers Yves

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is important for sleep physiology. This study investigates whether BDNF variants and promoter I methylation may be implicated in sleep disturbances in older adults. Genotyping was performed for seven BDNF single nucleotide polymorphisms (SNPs) in 355 community-dwelling older adults (aged ≥65 years) and BDNF exon 1 promoter methylation was measured in blood samples at...

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Identifiers

PMID: 36737401
DOI: 10.1111/jsr.13838
PMCID: PMC10909562

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