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Do Serum Urate-Associated Genetic Variants Differentially Contribute to Gout Risk According to Body Mass Index? Analysis of the UK Biobank.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2020

Tai Vicky, Narang Ravi K, Gamble Greg, Cadzow Murray, Stamp Lisa K, Merriman Tony R, Dalbeth Nicola

Abstract excerpt

OBJECTIVE: To examine whether urate-associated genetic variants differ in their influence on gout risk according to body mass index (BMI). METHODS: This research was conducted using the UK Biobank Resource (n = 358,728). Participants were divided into 3 groups: BMI <25 kg/m2 (low/normal), BMI ≥25 kg/m2 -<30 kg/m2 (overweight), and BMI ≥30 kg/m2 (obese). Gene-BMI interactions for gout association were tested by...

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PMID: 32017447
DOI: 10.1002/art.41219

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