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Article

Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index.

Rheumatology international - 1 Feb 2016

Reynolds Richard J, Vazquez Ana I, Srinivasasainagendra Vinodh, Klimentidis Yann C, Bridges S Louis, Allison David B, Singh Jasvinder A

Abstract excerpt

We hypothesized that serum urate-associated SNPs, individually or collectively, interact with BMI and renal disease to contribute to risk of incident gout. We measured the incidence of gout and associated comorbidities using the original and offspring cohorts of the Framingham Heart Study. We used direct and imputed genotypes for eight validated serum urate loci. We fit binomial regression models of gout...

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PMID: 26427508
DOI: 10.1007/s00296-015-3364-4
PMCID: PMC4724568

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