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Article

Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing.

The Journal of antimicrobial chemotherapy - 2 Mar 2023

Wagner Theresa Maria, Howden Benjamin Peter, Sundsfjord Arnfinn, Hegstad Kristin

Abstract excerpt

Acquisition and expression of antimicrobial resistance (AMR) mechanisms in bacteria are often associated with a fitness cost. Thus, evolutionary adaptation and fitness cost compensation may support the advance of subpopulations with a silent resistance phenotype when the antibiotic selection pressure is absent. However, reports are emerging on the transient nature of silent acquired AMR, describing genetic...

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PMID: 36719135
DOI: 10.1093/jac/dkad024
PMCID: PMC9978586

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