Article
Bi-allelic human TEKT3 mutations cause male infertility with oligoasthenoteratozoospermia owing to acrosomal hypoplasia and reduced progressive motility.
Human molecular genetics - 5 May 2023
Liu Yiyuan, Li Yuqian, Meng Lanlan, Li Kuokuo, Gao Yang, Lv Mingrong, Guo Rui, Xu Yuping, Zhou Ping, Wei Zhaolian, He Xiaojin, Cao Yunxia, Wu Huan, Tan Yueqiu, Hua Rong
Abstract excerpt
Oligoasthenoteratozoospermia (OAT) can result in male infertility owing to reduced sperm motility and abnormal spermatozoan morphology. The Tektins are a family of highly conserved filamentous proteins expressed in the axoneme and associated structures in many different metazoan species. Earlier studies on mice identified Tektin3 (Tekt3) as a testis-enriched gene, and knockout of Tekt3 resulted in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.