Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies.

doi:10.1016/j.jacc.2016.09.927

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Article

Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies.

Journal of the American College of Cardiology - 6 Dec 2016

Ortiz-Genga Martín F, Cuenca Sofía, Dal Ferro Matteo, Zorio Esther, Salgado-Aranda Ricardo, Climent Vicente, Padrón-Barthe Laura, Duro-Aguado Iria, Jiménez-Jáimez Juan, Hidalgo-Olivares Víctor M, García-Campo Enrique, Lanzillo Chiara, Suárez-Mier M Paz, Yonath Hagith, Marcos-Alonso Sonia, Ochoa Juan P, Santomé José L, García-Giustiniani Diego, Rodríguez-Garrido Jorge L, Domínguez Fernando, Merlo Marco, Palomino Julián, Peña María L, Trujillo Juan P, Martín-Vila Alicia, Stolfo Davide, Molina Pilar, Lara-Pezzi Enrique, Calvo-Iglesias Francisco E, Nof Eyal, Calò Leonardo, Barriales-Villa Roberto, Gimeno-Blanes Juan R, Arad Michael, García-Pavía Pablo, Monserrat Lorenzo

Abstract excerpt

BACKGROUND: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment to the plasmatic membrane. FLNC mutations have been associated with myofibrillar myopathies, and cardiac involvement has been reported in some carriers. Accordingly, since 2012, the authors have included FLNC in the genetic screening of patients with inherited cardiomyopathies and sudden death. OBJECTIVES: The aim of this study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27908349
DOI: 10.1016/j.jacc.2016.09.927

Genes

FLNC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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