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Article

Concordance between cancer gene alterations in tumor and circulating tumor DNA correlates with poor survival in a real-world precision-medicine population.

Molecular oncology - 1 Sept 2023

Rosenberg Shai, Ben Cohen Gil, Kato Shumei, Okamura Ryosuke, Lippman Scott M, Kurzrock Razelle

Abstract excerpt

Genomic analysis, performed on tumoral tissue DNA and on circulating tumor DNA (ctDNA) from blood, is the cornerstone of precision cancer medicine. Herein, we characterized the clinical prognostic implications of the concordance of alterations in major cancer genes between tissue- and blood-derived DNA in a pan-cancer cohort. The molecular profiles of both liquid (Guardant Health) and tissue (Foundation Medicine)...

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Identifiers

PMID: 36694946
DOI: 10.1002/1878-0261.13383
PMCID: PMC10483598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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