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Article

Causal relationships between gut metabolites and Alzheimer's disease: a bidirectional Mendelian randomization study.

Neurobiology of aging - 1 Apr 2021

Zhuang Zhenhuang, Gao Meng, Yang Ruotong, Liu Zhonghua, Cao Weihua, Huang Tao

Abstract excerpt

Observational studies have shown that gut microbiota-dependent metabolites are associated with the risk of Alzheimer's disease (AD). However, whether such association reflects a causality remains unclear. We conducted a bidirectional Mendelian randomization analysis to examine the causal relationships between gut microbiota-dependent metabolites trimethylamine N-oxide (TMAO) or its predecessors and AD. We...

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Alzheimer Disease
Betaine
Carnitine
Choline
Gastrointestinal Microbiome

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Mendelian Randomization Analysis

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PMID: 33280888
DOI: 10.1016/j.neurobiolaging.2020.10.022

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