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Article

Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families.

Frontiers in endocrinology - 1 Jan 2022

Meng Zhixiang, Meng Qingxia, Gao Tingting, Zhou Hui, Xue Jiajia, Li Hong, Wu Yibo, Lv Jinxing

Abstract excerpt

Introduction: Asthenozoospermia (AZS) is a leading cause of male infertility, affecting an estimated 18% of infertile patients. Kinesin proteins function as molecular motors capable of moving along microtubules. The highly conserved kinesin family member 9 (KIF9) localizes to the central microtubule pair in the flagella of Chlamydomonas cells. The loss of KIF9 expression in mice has been linked to AZS phenotypes....

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Identifiers

PMID: 36686457
DOI: 10.3389/fendo.2022.1091107
PMCID: PMC9846173

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