Article
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
American journal of hematology - 1 May 2023
Tefferi Ayalew
Abstract excerpt
DISEASE OVERVIEW: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional features include bone marrow reticulin/collagen fibrosis, aberrant inflammatory cytokine expression, anemia, hepatosplenomegaly, extramedullary hematopoiesis (EMH), constitutional...
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