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Polymorphisms of Antioxidant Enzymes SOD2 (rs4880) and GPX1 (rs1050450) Are Associated with Bladder Cancer Risk or Its Aggressiveness.

Medicina (Kaunas, Lithuania) - 9 Jan 2023

Nikic Predrag, Dragicevic Dejan, Jerotic Djurdja, Savic Slaviša, Djukic Tatjana, Stankovic Branko, Kovacevic Luka, Simic Tatjana, Matic Marija

Abstract excerpt

Background and Objectives: Oxidative stress induced by increased reactive oxygen species (ROS) production plays an important role in carcinogenesis. The entire urinary tract is continuously exposed to numerous potentially mutagenic environmental agents which generate ROS during their biotransformation. In first line defense against free radicals, antioxidant enzymes superoxide dismutase (SOD2) and glutathione...

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Source

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Identifiers

PMID: 36676755
DOI: 10.3390/medicina59010131
PMCID: PMC9860962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms of Antioxidant Enzymes SOD2 (rs4880) and GPX1 (rs1050450) Are Associated with Bladder Cancer Risk or Its Aggressiveness.PMID 36676755Read ↗

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