Article
Influence of HLADQA1*05 Genotype in Adults With Inflammatory Bowel Disease and Anti-TNF Treatment With Proactive Therapeutic Drug Monitoring: A Retrospective Cohort Study.
Inflammatory bowel diseases - 3 Oct 2023
Fuentes-Valenzuela Esteban, García-Alonso Francisco Javier, Maroto-Martín Carlos, Juan Casamayor Laura, Garrote José Antonio, Almendros Muñoz Rosendo, De Prado Ángel, Vara Castrodeza Alejando, Marinero María Ángeles, Calleja Carbajosa Raquel, Barrio Jesús
Abstract excerpt
BACKGROUND: Carriers of the human leucocyte antigen variant HLADQA1*05 (rs2097432) are at risk of developing antibodies against infliximab and adalimumab with reduced tumor necrosis factor (TNF) antagonist persistence. The impact of proactive therapeutic drug monitoring (PTDM) on this association has been barely assessed. METHODS: We conducted a retrospective single-center cohort study including patients with...
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