Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients

20 Jan 2023

Abstract excerpt

Sex-biased humoral immune responses to COVID-19 patients have been observed, but the cellular basis for this is not understood. Using single-cell proteomics by mass cytometry, we find disrupted regulation of humoral immunity in COVID-19 patients, with a sex-biased loss of circulating follicular regulatory T cells (cTfr) at a significantly greater rate in male patients. In addition, a male sex-associated cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to SARS-CoV-2 and COVID-19 Research
Share to Single-cell and spatial transcriptomics
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36669118
DOI: 10.1073/pnas.2217902120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patientsPMID 36669118Read ↗

Regulatory T-cells are central hubs for age-, sex- and severity-associated cellular networks during COVID-19Semantic proximity Read ↗

Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19Semantic proximity Read ↗

Immunophenotyping for Risk Stratification of Patients with COVID-19Semantic proximity Read ↗

Imbalanced Immune Response of T-Cell and B-Cell Subsets in Patients with Moderate and Severe COVID-19Semantic proximity Read ↗

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19Semantic proximity Read ↗

Persistent Immune Dysregulation during Post-Acute Sequelae of COVID-19 is Manifested in Antibodies Targeting Envelope and Nucleocapsid ProteinsSemantic proximity Read ↗

Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiencySemantic proximity Read ↗

Longitudinal dynamic single-cell mass cytometry analysis of peripheral blood mononuclear cells in COVID-19 patients within 6 months after viral RNA clearanceSemantic proximity Read ↗

In-depth immune profiling reveals advanced B- and T-cell differentiation to be associated with Th1-driven immune dysregulation in common variable immunodeficiency.Semantic proximity Read ↗

Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19Semantic proximity Read ↗

Maturation Trajectories and Transcriptional Landscape of Plasmablasts and Autoreactive B Cells in COVID-19Semantic proximity Read ↗

A streamlined whole blood CyTOF workflow defines a circulating immune cell signature of COVID ‐19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.