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Article

Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD.

Respiratory research - 19 Jan 2023

Verstraete Kenneth, Das Nilakash, Gyselinck Iwein, Topalovic Marko, Troosters Thierry, Crapo James D, Silverman Edwin K, Make Barry J, Regan Elizabeth A, Jensen Robert, De Vos Maarten, Janssens Wim

Abstract excerpt

BACKGROUND: Parameters from maximal expiratory flow-volume curves (MEFVC) have been linked to CT-based parameters of COPD. However, the association between MEFVC shape and phenotypes like emphysema, small airways disease (SAD) and bronchial wall thickening (BWT) has not been investigated. RESEARCH QUESTION: We analyzed if the shape of MEFVC can be linked to CT-determined emphysema, SAD and BWT in a large cohort...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36658542
DOI: 10.1186/s12931-023-02318-4
PMCID: PMC9854102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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