Article
Subphenotypes of mild-to-moderate COPD by factor and cluster analysis of pulmonary function, CT imaging and breathomics in a population-based survey.
COPD - 1 Jun 2013
Fens Niki, van Rossum Annelot G J, Zanen Pieter, van Ginneken Bram, van Klaveren Rob J, Zwinderman Aeilko H, Sterk Peter J
Abstract excerpt
INTRODUCTION: Classification of COPD is currently based on the presence and severity of airways obstruction. However, this may not fully reflect the phenotypic heterogeneity of COPD in the (ex-) smoking community. We hypothesized that factor analysis followed by cluster analysis of functional, clinical, radiological and exhaled breath metabolomic features identifies subphenotypes of COPD in a community-based...
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