Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replica-exchange optimization of antibody fragments.

Computational biology and chemistry - 1 Apr 2023

Soler Miguel A, Minovski Nikola, Rocchia Walter, Fortuna Sara

Abstract excerpt

In the framework of the rational design of macromolecules capable of binding to a specific target for biosensing applications, we here further develop an evolutionary protocol designed to optimize the binding affinity of protein binders. In particular we focus on the optimization of the binding portion of small antibody fragments known as nanobodies (or VHH) and choose the hen egg white lysozyme (HEWL) as our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chickens
Share to Immunoglobulin Fragments
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Single-Domain Antibodies

Source

Identifiers

PMID: 36657284
DOI: 10.1016/j.compbiolchem.2023.107819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replica-exchange optimization of antibody fragments.PMID 36657284Read ↗

A consensus protocol for the in silico optimisation of antibody fragments.Semantic proximity Read ↗

Computational optimization of antibody humanness and stability by systematic energy-based rankingSemantic proximity Read ↗

Molecular dynamics simulations and docking enable to explore the biophysical factors controlling the yields of engineered nanobodies.Semantic proximity Read ↗

Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions.Semantic proximity Read ↗

Lessons learned from merging wet lab experiments with molecular simulation to improve mAb humanization.Semantic proximity Read ↗

Computational Mutagenesis of Antibody Fragments: Disentangling Side Chains from ΔΔG Predictions.Semantic proximity Read ↗

Disulfide bond introduction for general stabilization of immunoglobulin heavy-chain variable domains.Semantic proximity Read ↗

The chemistry of the antibody molecule.Semantic proximity Read ↗

ModiBodies: A computational method for modifying nanobodies to improve their antigen binding affinity and specificitySemantic proximity Read ↗

Stability engineering of antibody single-chain Fv fragments.Semantic proximity Read ↗

Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten.Semantic proximity Read ↗

Tailoring in vitro evolution for protein affinity or stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.