Computational Mutagenesis of Antibody Fragments: Disentangling Side Chains from ΔΔG Predictions.

Abstract excerpt

The development of highly potent antibodies and antibody fragments as binding agents holds significant implications in fields such as biosensing and biotherapeutics. Their binding strength is intricately linked to the arrangement and composition of residues at the binding interface. Computational techniques offer a robust means to predict the three-dimensional structure of these complexes and to assess the...

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• Antibodies
• Immunoglobulin Fragments
• Mutagenesis
• Mutation
• Point Mutation