Article
Molecular-Targeted Therapy of Pediatric Acute Myeloid Leukemia.
Molecules (Basel, Switzerland) - 18 Jun 2022
Obszański Piotr, Kozłowska Anna, Wańcowiat Jakub, Twardowska Julia, Lejman Monika, Zawitkowska Joanna
Abstract excerpt
Acute myeloid leukemia (AML) accounts for approximately 15-20% of all childhood leukemia cases. The overall survival of children with acute myeloid leukemia does not exceed 82%, and the 5-year event-free survival rates range from 46% to 69%. Such suboptimal outcomes are the result of numerous mutations and epigenetic changes occurring in this disease that adversely affect the susceptibility to treatment and...
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