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Article

A hierarchy of cell death pathways confers layered resistance to shigellosis in mice

16 Jan 2023

Abstract excerpt

Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease driven by bacterial colonization of colonic intestinal epithelial cells. Vertebrates have evolved programmed cell death pathways that sense invasive enteric pathogens and eliminate their intracellular niche. Previously we reported that genetic removal of one such pathway, the NAIP–NLRC4 inflammasome, is sufficient to convert mice...

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PMID: 36645406
DOI: 10.7554/elife.83639

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