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The ShiA protein encoded by theShigella flexneriSHI-2 pathogenicity island attenuates inflammation

15 Oct 2003

Abstract excerpt

Shigella spp. are the aetiologic agents of dysentery, a severe diarrhoeal syndrome characterized by acute inflammation in the colon. The inflammatory response, which includes recruitment of polymorphonuclear leukocytes (PMN), damages the colonic mucosa and exacerbates the infection. Shigella encodes a pathogenicity island (PAI), SHI-2, which is localized in a region of the chromosome linked to the induction of...

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PMID: 14531895
DOI: 10.1046/j.1462-5822.2003.00320.x

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