Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NAIP–NLRC4-deficient mice are susceptible to shigellosis

19 Oct 2020

Abstract excerpt

Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease that is a major cause of diarrhea-associated mortality in humans. Mice are highly resistant to Shigella and the lack of a tractable physiological model of shigellosis has impeded our understanding of this important human disease. Here, we propose that the differential susceptibility of mice and humans to Shigella is due to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli research studies
Share to Inflammasome and immune disorders
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33074100
DOI: 10.7554/elife.59022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NAIP–NLRC4-deficient mice are susceptible to shigellosisPMID 33074100Read ↗

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γSemantic proximity Read ↗

A hierarchy of cell death pathways confers layered resistance to shigellosis in miceSemantic proximity Read ↗

The NAIP/NLRC4 inflammasomes.Semantic proximity Read ↗

Animal models of shigellosis: a historical overviewSemantic proximity Read ↗

A hierarchy of cell death pathways confers layered resistance to shigellosis in miceSemantic proximity Read ↗

Recent advances in modelling Shigella infectionSemantic proximity Read ↗

A new paradigm of bacteria-gut interplay brought through the study of <bold>Shigella</bold>Semantic proximity Read ↗

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal MucosaSemantic proximity Read ↗

An animal model for autoinflammation with infantile enterocolitisSemantic proximity Read ↗

Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replicationSemantic proximity Read ↗

The Bacterial WeaponrySemantic proximity Read ↗

Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.