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Ascorbate deficiency increases progression of shigellosis in guinea pigs and mice infection models

24 Oct 2023

Abstract excerpt

Shigella spp. are the causative agents of bacterial dysentery and shigellosis, mainly in children living in developing countries. The study of Shigella entire life cycle in vivo and the evaluation of vaccine candidates’ protective efficacy have been hampered by the lack of a suitable animal model of infection. None of the studies evaluated so far (rabbit, guinea pig, mouse) allowed the recapitulation of full...

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PMID: 37876025
DOI: 10.1080/19490976.2023.2271597

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