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Article

Coupled induction of prophage and virulence factors during tick transmission of the Lyme disease spirochete

13 Jan 2023

Abstract excerpt

The alternative sigma factor RpoS plays a central role in the critical host-adaptive response of the Lyme disease spirochete, Borrelia burgdorferi. We previously identified bbd18 as a negative regulator of RpoS but could not inactivate bbd18 in wild-type spirochetes. In the current study we employed an inducible bbd18 gene to demonstrate the essential nature of BBD18 for viability of wild-type spirochetes in...

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PMID: 36639656
DOI: 10.1038/s41467-023-35897-3

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